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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are typically described by their focus on practical aspects of designing a study which include recruitment and consent, adherence and the use of routinely available equipment.

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A pragmatic trial that uses various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for practical trials to be valid, and it also reduces the chance of bias in the results. However, too much heterogeneity can result in problems with the trial design.

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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually requested by policy makers and practitioners to inform their decision making. They also provide a useful way to identify the causal relationship between the intervention and its effects. They should, 프라그마틱 무료스핀 however, not be used to replace explanation studies.

The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also suggested the framework for pragmatic trials, 프라그마틱 슬롯 사이트 called PRECIS.2 This tool attempted to define the characteristics of a practical trial that include recruitment, design and delivery of the intervention, 프라그마틱 무료 as well as monitoring.

The number of pragmatic trials is growing. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health science community is becoming more sensitive to the issue of pragmatic thinking. It is important to keep in mind that the majority of these studies were conducted in primary care settings.