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Pragmatic trials are those that are designed to inform real-world clinical practice. They are often characterized as focusing on practical aspects of study design that include recruitment and consent, adherence and the use routinely available equipment.

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A pragmatic trial that uses various investigators and 무료 프라그마틱 participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for pragmatic trials to be reliable and lessen the chance of bias is also essential. However, too much heterogeneity, can cause problems with the trial design.

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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are typically commissioned by policy makers and practitioners to aid in their decision-making. They can be used to determine the cause-effect relationship of an intervention and its effects. However, they shouldn't be used in lieu for explanatory trials.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they are an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm a physiological or clinical hypothesis as well as pragmatic trials that inform policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a practical study, including recruitment, design, implementation of the intervention and follow-up.

There is an encouraging trend in the number of pragmatic trials published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to remember that the majority of these trials were conducted in primary care settings.