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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often characterized as focusing on practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and had participants from different geographical regions. This type of heterogeneity is necessary for pragmatic trials to be able to prove their validity, and it also helps to reduce the chance of bias in the results. However excessive heterogeneity could lead to problems with the design of the trial.

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The goal of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. They are typically requested by practitioners and policymakers to inform their decisions. They are also a good method to determine the causal relationship between an intervention and its outcomes. They should not, however, be used to replace explanatory studies.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace tests for explanations or if they should be an addition to them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which confirm the validity of a physiological or clinical hypothesis, and pragmatic trials, which inform policy and practice decision-making. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic study, including recruitment, design and 프라그마틱 무료체험 (visit the following page) delivery of the intervention, and follow-up.

There is a growing increase in the number of pragmatic trials that have been published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs), yielded 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming more sensitive to the issue of pragmatic thinking. It is important to note, however, that the majority of studies were conducted in primary care settings.