Five Pragmatic Free Trial Lessons From The Pros

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Pragmatic trials are those that are designed to provide information for real-world clinical practice. They are typically characterized by a focus on the practical aspects of study design, such as the recruitment process and consent, adherence, and the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and had participants from different geographic areas. This type of heterogeneity, which is vital for pragmatic trials to be reliable and reduce bias in results, is also necessary. A high degree of heterogeneity, however can result in problems with the trial design.

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Mobile compatibility

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Legality

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The aim of pragmatic trials is to mimic real-life scenarios and to achieve maximum credibility externally. They are usually requested by policy makers and practitioners to aid in their decision-making. They can also be used to assess the causal relationship between an intervention with its outcomes. However, they shouldn't be used as a substitute for explanatory studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis and pragmatic trials, which inform the policy and practice of. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool sought to define the elements of a pragmatic trial, including recruitment, design and delivery of the intervention, as well as the follow-up.

The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, limited to randomized controlled trials (RCTs) resulted in 34 articles, as shown in red in Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the subject of pragmatism. It is important to note, however, that the majority of these studies were conducted in primary-care settings.