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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically described as focusing on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use routinely available equipment.

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A practical trial that employs various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for pragmatic trials to be able to prove their validity and also helps to reduce bias in the results. Too much heterogeneity, however could cause issues with the trial design.

Pragmatic Play is one of the major players in the live casino market offers various classic table games like Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta provide customers with an authentic gaming experience as well a full selection of virtual betting options. The company also has several game shows that make online gambling more enjoyable and engaging. Some of these shows are broadcast live and some include famous people from the field.

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Pragmatic Play is a new player in the online casino market however, it has established itself through its mobile-friendly slot machines. Their games are optimized for mobile devices and run on HTML5 technology. They are also licensed and regulated by reputable gaming authorities, ensuring fairness and transparency. This is a good indicator for players because it indicates that the games have been tested and validated in order to ensure the randomness and fairness of each round.

In addition to their mobile-friendly slots, Pragmatic Play also offers live dealer casinos. The company is licensed and regulated by a variety of governing bodies, including the Malta Gaming Authority and UK Gambling Commission. The games of the company are protected by high-end encryption and its security team is available to assist players in any situation.

Pragmatic Play's slot games are very popular among both newcomers as well as seasoned players. They have modern graphics and traditional themes. They have a variety of paylines and bonus rounds and many offer progressive jackpots. They are also not particularly volatile and you can expect to have a long-lasting gaming session with them.

Pragmatic Play offers a large selection of games you can play for free before you decide whether to pay for them. These games are free and can be played on any device including tablets, desktops, and even smartphones. You can play them wherever you have an internet connection. They are easy-to-navigate. Some Pragmatic Play sites even allow you to test your luck on the go with a practice mode. This allows you to get familiar with the game's rules and features before playing with real money.

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Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are usually commissioned by practitioners and policy makers to guide their decision-making. They also provide a useful method to determine the causal relationship between the intervention and its effects. However, they shouldn't be used as a substitute for explanation trials.

The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which confirm the validity of a physiological or clinical hypothesis, and pragmatic trials, that inform policy and practice decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic study which includes recruitment, design, implementation of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of studies were conducted in primary-care settings.